Why are Mounjaro and Ozempic only approved for the treatment of Type 2 diabetes when many people use the weekly injections off-label to lose weight?

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Ozempic and Mounjaro have a place with the class of drugs known as incretin mimetics, explicitly GLP-1 receptor agonists, which are intended to imitate the activity of normal stomach chemicals. These drugs act by restricting to and enacting the GLP-1 receptors, prompting different physiological reactions.


Ozempic (semaglutide) explicitly goes about as a GLP-1 receptor agonist. At the point when it ties to the GLP-1 receptors, it improves the emission of insulin from the pancreas, lessens the discharge of glucagon (a chemical that increments blood glucose levels), and dials back gastric purging. These activities all in all add to bring down blood glucose levels, making it a viable treatment choice for Type 2 diabetes. Moreover, the postponed gastric exhausting and expanded satiety add to a decrease in craving, which can prompt weight reduction.


Then again, Mounjaro is a special drug that goes about as a double agonist, focusing on both the GLP-1 and GIP (glucose-subordinate insulinotropic polypeptide) receptors. GIP is one more stomach chemical that animates insulin emission in light of food consumption. By focusing on both GLP-1 and GIP receptors, Mounjaro offers a more complete way to deal with glucose control and hunger guideline. The consolidated activity on the two receptors might bring about upgraded insulin discharge, diminished glucagon emission, eased back gastric purging, and expanded satiety, prompting improved glycemic control and possibly more huge weight reduction contrasted with prescriptions that target just the GLP-1 receptor.


In outline, while both Ozempic and Mounjaro are incretin mimetics that upgrade the activity of stomach chemicals to bring down blood glucose levels and lessen hunger, Mounjaro's double activity on both GLP-1 and GIP receptors might offer extra advantages as far as craving control and weight reduction. Nonetheless, the decision of drug ought to be individualized in light of a patient's particular requirements, clinical history, and in general treatment objectives.

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